Kubbutat, Michael H.G.: search on Z-Library

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1

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors

Barbosa, Maria Letícia de Castro, Lima, Lídia Moreira, Tesch, Roberta, Sant'Anna, Carlos Mauricio R., Totzke, Frank, Kubbutat, Michael H.G., Schächtele, Christoph, Laufer, Stefan A., Barreiro, Eliezer

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.34 MB

english, 2014

2

Development of First Lead Structures for Phosphoinositide 3-Kinase-C2γ Inhibitors

Freitag, Anne, Prajwal, Prajwal, Shymanets, Aliaksei, Harteneck, Christian, Nürnberg, Bernd, Schächtele, Christoph, Kubbutat, Michael, Totzke, Frank, Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.49 MB

english, 2015

3

Decalactone Derivatives from Corynespora cassiicola, an Endophytic Fungus of the Mangrove Plant Laguncularia racemosa

Weaam Ebrahim, Amal H. Aly, Attila Mándi, Frank Totzke, Michael H. G. Kubbutat, Victor Wray, Wen-Han Lin, Haofu Dai, Peter Proksch, Tibor Kurtán, Abdessamad Debbab

Journal:

European Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 582 KB

english, 2012

4

Cytotoxic Metabolites from the Fungal Endophyte Alternaria sp. and Their Subsequent Detection in Its Host Plant Polygonum senegalense

Aly, Amal H., Edrada-Ebel, RuAngelie, Indriani, Ine Dewi, Wray, Victor, Müller, Werner E. G., Totzke, Frank, Zirrgiebel, Ute, Schächtele, Christoph, Kubbutat, Michael H. G., Lin, W. H., Proksch, Pet

Journal:

Journal of Natural Products

Year:

2008

Language:

english

File:

PDF, 182 KB

english, 2008

5

Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation

Wim Wätjen, Abdessamad Debbab, Anke Hohlfeld, Yvonni Chovolou, Andreas Kampkötter, Ru Angelie Edrada, Rainer Ebel, Abdelhak Hakiki, Mahjouba Mosaddak, Frank Totzke, Michael H. G. Kubbutat, Peter Proks

Journal:

Molecular Nutrition & Food Research

Year:

2009

Language:

english

File:

PDF, 1.77 MB

english, 2009

6

Bioactive Metabolites from the Endophytic Fungus Stemphylium globuliferum Isolated from Mentha pulegium

Debbab, Abdessamad, Aly, Amal H., Edrada-Ebel, RuAngelie, Wray, Victor, Müller, Werner E. G., Totzke, Frank, Zirrgiebel, Ute, Schächtele, Christoph, Kubbutat, Michael H. G., Lin, Wen Han, Mosaddak,

Journal:

Journal of Natural Products

Year:

2009

Language:

english

File:

PDF, 102 KB

english, 2009

7

Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure

Stefanie Schmidt, Lutz Preu, Thomas Lemcke, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Conrad Kunick

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 627 KB

english, 2011

8

New HPV E6 binding proteins: dangerous liaisons?

Michael H.G Kubbutat, Karen H Vousden

Journal:

Trends in Microbiology

Year:

1998

Language:

english

File:

PDF, 117 KB

english, 1998

9

Search for Inhibitors of Bacterial and Human Protein Kinases among Derivatives of Diazepines[1,4] Annelated with Maleimide and Indole Cycles

Danilenko, Valery N., Simonov, Alexander Y., Lakatosh, Sergey A., Kubbutat, Michael H. G., Totzke, Frank, Schächtele, Christoph, Elizarov, Sergey M., Bekker, Olga B., Printsevskaya, Svetlana S., Luzi

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 514 KB

english, 2008

10

A novel reverse transduction adenoviral array for the functional analysis of shRNA libraries

Angelika Oehmig, Andrea Klotzbücher, Maria Thomas, Frank Weise, Ursula Hagner, Ralf Brundiers, Dirk Waldherr, Andreas Lingnau, Achim Knappik, Michael HG Kubbutat, Thomas O Joos, Hansjürgen Volkmer

Journal:

Year:

2008

Language:

english

File:

PDF, 3.82 MB

english, 2008

11

Assessing the Target Differentiation Potential of Imidazole-Based Protein Kinase Inhibitors

Dimova, Dilyana, Iyer, Preeti, Vogt, Martin, Totzke, Frank, Kubbutat, Michael H. G., Schächtele, Christoph, Laufer, Stefan, Bajorath, Jürgen

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 622 KB

english, 2012

12

New 3,4-bis(indol-1-yl)maleimides as protein kinase inhibitors

Panov, Alexey A., Lakatosh, Sergey A., Kubbutat, Michael H. G., Dezhenkova, Lyubov G., Totzke, Frank, Schechtel, Kristof

Journal:

Chemistry of Heterocyclic Compounds

Year:

2019

File:

PDF, 323 KB

2019

13

Corrigendum to “Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa” [Phytochemistry 71(4) (2010) 435–442]

Cui Shi, Min-Juan Xu, Mirko Bayer, Zhi-Wei Deng, Michael H.G. Kubbutat, Wim Wätjen, Peter Proksch, Wen-Han Lin

Journal:

Year:

2010

Language:

english

File:

PDF, 104 KB

english, 2010

14

Regulation of p53 stability by Mdm2

Kubbutat, Michael H. G., Jones, Stephen N., Vousden, Karen H.

Journal:

Year:

1997

File:

PDF, 3.48 MB

1997

15

2-Anilino-4-(benzimidazol-2-yl)pyrimidines – A multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines

Renate Determann, Jan Dreher, Knut Baumann, Lutz Preu, Peter G. Jones, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Conrad Kunick

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 646 KB

english, 2012

16

4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-kB cascade

Pippione, Agnese Chiara, Federico, Antonella, Ducime, Alex, Sainas, Stefano, boschi, donatella, Barge, Alessandro, LUPINO, Elisa, Piccinini, Marco, Kubbutat, Michael, Contreras, Jean Marie, Morice, Ch

Journal:

Year:

2017

Language:

english

File:

PDF, 1.07 MB

english, 2017

17

Inverse In Silico Screening for Identification of Kinase Inhibitor Targets

Stefan Zahler, Simon Tietze, Frank Totzke, Michael Kubbutat, Laurent Meijer, Angelika M. Vollmar, Joannis Apostolakis

Journal:

Chemistry & Biology

Year:

2007

Language:

english

File:

PDF, 738 KB

english, 2007

18

Cytotoxic effects of the anthraquinone derivatives 1′-deoxyrhodoptilometrin and (S)-(−)-rhodoptilometrin isolated from the marine echinodermComanthussp.

Wätjen, Wim, Ebada, Sherif S., Bergermann, Anja, Chovolou, Yvonni, Totzke, Frank, Kubbutat, Michael H. G., Lin, Wenhan, Proksch, Peter

Journal:

Archives of Toxicology

Year:

2017

Language:

english

File:

PDF, 1.04 MB

english, 2017

19

Structure-Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone

Conrad Kunick, Zhihong Zeng, Rick Gussio, Daniel Zaharevitz, Maryse Leost, Frank Totzke, Christoph Schächtele, Michael H. G. Kubbutat, Laurent Meijer, Thomas Lemcke

Journal:

Year:

2005

Language:

english

File:

PDF, 283 KB

english, 2005

20

Arthrinins A–D: Novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.

Sherif S. Ebada, Barbara Schulz, Victor Wray, Frank Totzke, Michael H.G. Kubbutat, Werner E.G. Müller, Alexandra Hamacher, Matthias U. Kassack, Wenhan Lin, Peter Proksch

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 337 KB

english, 2011

21

Contribution of two independent MDM2-binding domains in p14ARF to p53 stabilization

Marion A.E. Lohrum, Margaret Ashcroft, Michael H.G. Kubbutat, Karen H. Vousden

Journal:

Current Biology

Year:

2000

Language:

english

File:

PDF, 98 KB

english, 2000

22

Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa

Cui Shi, Min-Juan Xu, Mirko Bayer, Zhi-Wei Deng, Michael H.G. Kubbutat, Wim Waejen, Peter Proksch, Wen-Han Lin

Journal:

Year:

2010

Language:

english

File:

PDF, 468 KB

english, 2010

23

Hexa-, hepta- and nonaprenylhydroquinones isolated from marine sponges Sarcotragus muscarum and Ircinia fasciculata inhibit NF-k B signalling in H4IIE cells

Wim Wätjen, Annika Putz, Yvonni Chovolou, Andreas Kampkötter, Frank Totzke, Michael H.G. Kubbutat, Peter Proksch, Belma Konuklugil

Journal:

Journal of Pharmacy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 376 KB

english, 2009

24

Assessment of cell proliferation by means of an enzyme-linked immunosorbent assay based on the detection of the Ki-67 protein

Göran Key, Michael H.G. Kubbutat, Johannes Gerdes

Journal:

Journal of Immunological Methods

Year:

1994

Language:

english

File:

PDF, 385 KB

english, 1994

25

Regulation of p53 Function and Stability by Phosphorylation

Ashcroft, Margaret, Kubbutat, Michael H. G., Vousden, Karen H.

Journal:

Molecular and Cellular Biology

Year:

1999

Language:

english

File:

PDF, 2.07 MB

english, 1999

26

Matrix compare analysis discriminates subtle structural differences in a family of novel antiproliferative agents, diaryl-3-hydroxy-2,3,3a,10a-tetrahydrobenzo[b]cycylopenta[e]azepine-4,10(1H,5H)-diones

Conrad Kunick, Carola Bleeker, Christian Prühs, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Andreas Link

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 137 KB

english, 2006

27

Cause and consequence of becoming persistent: Persistent Viral Infections edited by R. Ahmed and I.S.Y. Chen

Michael H.G Kubbutat

Journal:

Trends in Microbiology

Year:

1999

Language:

english

File:

PDF, 80 KB

english, 1999

28

Keeping an old friend under control: regulation of p53 stability

Michael H.G Kubbutat PhD, Karen H Vousden PhD

Journal:

Molecular Medicine Today

Year:

1998

Language:

english

File:

PDF, 119 KB

english, 1998

29

Compounds isolated from Psoralea corylifolia seeds inhibit protein kinase activity and induce apoptotic cell death in mammalian cells

Limper, Christian, Wang, Yao, Ruhl, Sven, Wang, Zhiqiang, Lou, Yijia, Totzke, Frank, Kubbutat, Michael H.G., Chovolou, Yvonni, Proksch, Peter, Wätjen, Wim

Journal:

Journal of Pharmacy and Pharmacology

Year:

2013

Language:

english

File:

PDF, 1010 KB

english, 2013

30

Scaffold hopping identifies 6,8-disubstituted purines as novel anaplastic lymphoma kinase inhibitors

Schlütke, Laura, Immer, Markus, Preu, Lutz, Totzke, Frank, Schächtele, Christoph, Kubbutat, Michael H.G., Kunick, Conrad

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2017

Language:

english

File:

PDF, 739 KB

english, 2017

31

Identification of Inhibitors of the Tyrosine Kinase c-Met by Structure-Based Virtual Screening

Thomas Lemcke, Jan Dreher, Matthias Rarey, Frank Totzke, Christoph Schächtele, Michael H. G. Kubbutat, Conrad Kunick

Journal:

Molecular Informatics

Year:

2011

Language:

english

File:

PDF, 372 KB

english, 2011

32

Cytotoxic and Protein Kinase Inhibiting Nakijiquinones and Nakijiquinols from the Sponge Dactylospongia metachromia

Daletos, Georgios, de Voogd, Nicole J., Müller, Werner E. G., Wray, Victor, Lin, WenHan, Feger, Daniel, Kubbutat, Michael, Aly, Amal H., Proksch, Peter

Journal:

Journal of Natural Products

Year:

2014

Language:

english

File:

PDF, 642 KB

english, 2014

33

Synthesis and Structure of Fluorescent Chelate Boron Complexes of 4-Anilinomethylidene-1-benzazepine-2,5-dione Ligands

Tolle, Nadine, Dunkel, Ute, Oehninger, Luciano, Ott, Ingo, Preu, Lutz, Haase, Tobias, Behrends, Soenke, Jones, Peter, Totzke, Frank, Schächtele, Christoph, Kubbutat, Michael, Kunick, Conrad

Journal:

Year:

2011

File:

PDF, 27 KB

2011

34

10.1038/35004057

Vousden, Karen H., Lohrum, Marion A. E., Ashcroft, Margaret, Kubbutat, Michael H. G.

Journal:

Nature Cell Biology

Year:

2000

Language:

english

File:

PDF, 225 KB

english, 2000

35

Regulation of Mdm2-Directed Degradation by the C Terminus of p53

Kubbutat, Michael H. G., Ludwig, Robert L., Ashcroft, Margaret, Vousden, Karen H.

Journal:

Molecular and Cellular Biology

Year:

1998

Language:

english

File:

PDF, 1.32 MB

english, 1998

36

ChemInform Abstract: Dual IGF-1R/SRC Inhibitors Based on a N′-Aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide Structure.

Stefanie Schmidt, Lutz Preu, Thomas Lemcke, Frank Totzke, Christoph Schaechtele, Michael H. G. Kubbutat, Conrad Kunick

Journal:

Year:

2011

Language:

english

File:

PDF, 39 KB

english, 2011

37

ChemInform Abstract: 2-Anilino-4-(benzimidazol-2-yl)pyrimidines — A Multikinase Inhibitor Scaffold with Antiproliferative Activity Toward Cancer Cell Lines.

Renate Determann, Jan Dreher, Knut Baumann, Lutz Preu, Peter G. Jones, Frank Totzke, Christoph Schaechtele, Michael H. G. Kubbutat, Conrad Kunick

Journal:

Year:

2012

Language:

english

File:

PDF, 32 KB

english, 2012

38

Role of E6 and E7 oncoproteins in HPV-induced anogenital malignancies

Michael H.G. Kubbutat, Karen H. Vousden

Journal:

Seminars in Virology

Year:

1996

Language:

english

File:

PDF, 102 KB

english, 1996

39

N-substituted 2′-(aminoaryl)benzothiazoles as kinase inhibitors: Hit identification and scaffold hopping

Stefan Tasler, Oliver Müller, Tanja Wieber, Thomas Herz, Rolf Krauss, Frank Totzke, Michael H.G. Kubbutat, Christoph Schächtele

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 3.30 MB

english, 2009

40

1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: A new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines

Simone Kohfeld, Peter G. Jones, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Conrad Kunick

Journal:

European Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 286 KB

english, 2007

41

Substituted 2-arylbenzothiazoles as kinase inhibitors: Hit-to-lead optimization

Stefan Tasler, Oliver Müller, Tanja Wieber, Thomas Herz, Stefano Pegoraro, Wael Saeb, Martin Lang, Rolf Krauss, Frank Totzke, Ute Zirrgiebel, Jan E. Ehlert, Michael H.G. Kubbutat, Christoph Schächtele

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.58 MB

english, 2009

42

Workflow Comparison for Label-Free, Quantitative Secretome Proteomics for Cancer Biomarker Discovery: Method Evaluation, Differential Analysis, and Verification in Serum

Piersma, Sander R., Fiedler, Ulrike, Span, Simone, Lingnau, Andreas, Pham, Thang V., Hoffmann, Steffen, Kubbutat, Michael H. G., Jiménez, Connie R.

Journal:

Journal of Proteome Research

Year:

2010

Language:

english

File:

PDF, 1.06 MB

english, 2010

43

Regulation of HDM2 activity by the ribosomal protein L11

Marion A.E Lohrum, Robert L Ludwig, Michael H.G Kubbutat, Mary Hanlon, Karen H Vousden

Journal:

Year:

2003

Language:

english

File:

PDF, 435 KB

english, 2003

44

Trimeric Hemibastadin Congener from the Marine Sponge Ianthella basta

Niemann, Hendrik, Lin, Wenhan, Müller, Werner E. G., Kubbutat, Michael, Lai, Daowan, Proksch, Peter

Journal:

Journal of Natural Products

Year:

2013

Language:

english

File:

PDF, 939 KB

english, 2013

45

Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases

Thaher, Bassam Abu, Arnsmann, Martina, Totzke, Frank, Ehlert, Jan E., Kubbutat, Michael H. G., Schächtele, Christoph, Zimmermann, Markus O., Koch, Pierre, Boeckler, Frank M., Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.82 MB

english, 2012

46

Identification of 2-Anilino-9-methoxy-5,7-dihydro-6 H -pyrimido[5,4- d ][1]benzazepin-6-ones as Dual PLK1/VEGF-R2 Kinase Inhibitor Chemotypes by Structure-Based Lead Generation

Egert-Schmidt, Anne-Marie, Dreher, Jan, Dunkel, Ute, Kohfeld, Simone, Preu, Lutz, Weber, Holger, Ehlert, Jan E., Mutschler, Bettina, Totzke, Frank, Schächtele, Christoph, Kubbutat, Michael H. G., Bau

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.10 MB

english, 2010

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